The mononucleosis syndrome in leprosy patients treated with sulfones.

Dapsone syndrome with acute renal failure during leprosy treatment: case report.

Dapsone syndrome is a rare hypersensitivity reaction to dapsone and is characterized by high fever, papular or exfoliative dermatitis, progressing to liver toxicity and generalized lymphadenopathy, resembling a mononucleosis infection. We report a patient who developed acute renal failure, as well as other complications characteristic of dapsone syndrome, during leprosy treatment. Renal involve...

Electron microscope study of the dental pulp of lepromatous patients.

Stud ies of histopathologic changes in denta l lesions of leprosy patients were reported by Kitami (6), Tochihara and Murakami Cl), Hirashita (~,:I) , T ajiri and Kamio (X), I takura ( .1), Kamio (f.), and Asano (1). Most of the papers of these authors were published during the period before sulfones were used in Japan, On ly the paper of Asano belongs to the later period, when sulfones were em...

Approaches to clinical research.

The effi cacy of the sulfones in the trea tment of leprosy was proven in a controll ed study by Doull et al. (5), but, because it takes several years to arrest the disease in a case of leprosy and make it bacteriologically negative, search for more effective drugs has continued to the present time. Several drugs found effective in human leprosy have been evaluated by Doull (5) and Doull et aT. ...

Studies on Sulfone Resistance in Leprosy

Almost to be expected, as the concomitant of a new chemotherapeutic agent, is the development of drug resistance by formerly sensitive organisms. Sometimes this is such a frequen t occurrence that the drug ceases to be useful ; with other drugs the appearance of resistant strains is a rarity. Throughout the twenty year experience with sulfones in leprosy, the incidence of resistance has appeare...

Antimalarial studies on 4,4-diaminodiphenyl sulfone (DDS) and repository sulfones in experimental animals.